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附属仁济医院生物人工肝治疗肝衰竭研究获重大突破
2019-07-09 浏览( 来源:仁济医院 
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7YUE9RI,SHANGHAIJIAOTONGDAXUEYIXUEYUANFUSHURENJIYIYUANYANHEXIN、ZHAIBO、YUWEIFENGJIAOSHOUTUANDUIDENGYUSHANGHAISAILIWEISHENGWUKEJIYOUXIANGONGSIZAIGUOJIDINGJIZHUANHUAYIXUEQIKAN《KEXUEZHUANHUAYIXUE》(Science Translational Medicine)ZAZHISHANGHEZUOFABIAOTIWEI“An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs”DEYANJIULUNWEN。LUNWENCHANSHULESHENGWURENGONGGANJISHUDEJIBENGONGZUOYUANLI,YIJIGAIXIANGJISHUYONGYUSHIYANDONGWUDEANQUANXINGHEYOUXIAOXINGYANJIUJIEGUO。GAIYANJIUTUPOLESHENGWURENGONGGANDEGUANJIANJISHUPINGJING,WEIGANSHUAIJIEHUANZHETIGONGLEQUANXINDEZHILIAOFANGFAHEJIEJUEFANGAN。

WOGUOSHISHIJIESHANGGANBINGZUIYANZHONGDEGUOJIA,YOUJIEJIN4YIDEGANBINGHUANZHE(ZHANRENKOUZONGSHU25%~35%),MEINIANYUEYOU30-50WANRENFAZHANWEIGANSHUAIJIE。GANYIZHISHUSHIMUQIANZUIYOUXIAODEZHILIAOSHOUDUAN,DANJUANXIANGANZANGYUANBUNENGMANZUGANYIZHISHUDEXUQIU。

极速飞艇SHENGWURENGONGGANTIGONGLEYIZHONGTIDAISHOUDUAN,KEDUANSHIJIANTIDAIGANZANGDEGONGZUO,BINGCUJINSHOUSUNGANZANGZAISHENGXIUFU,KEBANGZHUBUFENGANSHUAIJIEHUANZHEHUIFUGANGONGNENGERBUZAIXUYAOGANYIZHI。DUIYUDENGDAIGANYIZHIDEYANZHONGGANSHUAIJIEHUANZHE,KEBANGZHUWEICHISHENGMINGZUOWEIGUODUDAOGANYIZHIDEQIAOLIANG。SHENGWURENGONGGANZHILIAOCELVEDETICHUDUITIGAOWOGUORENMINJIANKANGSHUIPINGHEJIANGDIGUOJIAYILIAOJINGJIFUDANJUYOUZHONGDAYIYI,YOUQIWEIJIMANXINGGANSHUAIJIEHUANZHE、GANYIZHIDENGDAIHUANZHE、GANYIZHISHUHOUYIZHIGANWUGONGNENGDEHUANZHETIGONGXINDEZHILIAOCELVE。

SHENGWURENGONGGAN(Bioartificial liver,BAL)DEJIBENYUANLISHIJIANGHUANZHEXUEJIANGTONGGUOTIWAIXUNHUANYUSHENGWUFANYINGQIZHONGDERENGANXIBAOJINXINGWUZHIJIAOHUAN,DUANSHIJIANTIDAIGANZANGGONGZUO,BINGCUJINSHOUSUNGANZANGZAISHENGXIUFU。GANXIBAOHEFANYINGQISHISHENGWURENGONGGANDELIANGDAHEXINYAOSU,GANXIBAOZAIFANYINGQIZHONGGONGNENGDEHAOHUAIYIJIGANXIBAOYUBINGRENXUEJIANGWUZHIJIAOHUANXIAOLVDEGAODIZHIJIEGUANXIDAOSHENGWURENGONGGANDEZHILIAOXIAOGUO。

MUQIANYONGYUBALDEGANXIBAOLAIYUANYOURENYUANDAIGANXIBAO、ZHUYUANDAIGANXIBAO、GANZHONGLIUXIBAO、YOUDAOFENHUAGANXIBAODENG,DANSHANGSHUXIBAOCUNZAILAIYUANDUANQUE、YIZHONGBINGDU、ZHILIUFENGXIAN、CHENGBENGAOANGDENGWENTI;SHENGWURENGONGGANDELINGYIHEXINYAOSUSHIFANYINGQI,CHANGJIANDESHENGWUFANYINGQIYOUZHONGKONGXIANWEI、PIANCENGPINGBANYIJIXIBAOXUANFUQIUFANYINGQIDENG,DANZAIYINGYONGZHONGCUNZAIJIAOHUANMIANJIYOUXIAN、YANGQIHEYINGYANGWUZHIJIAOHUANXIAOLVDI、WUFAXINGCHENGWENDINGDE3DJIEGOUDENG,JIDADEJIANGDILEGANXIBAODEWUZHIJIAOHUAN、JIEDUDEXIAOLV。

极速飞艇YANHEXINTUANDUILIYONGXIAOFENZIZHONGXINBIANCHENGJISHUJIANGRENYUANDAIGANXIBAOZHUANHUAWEIKEYIKUAISUZENGZHIDEGANQIANTIYANGXIBAO(hepatocyte-derived liver progenitor-like cells,HepLPCs),BUJINJIEJUELEYUANDAIGANXIBAOZAITIWAIWUFAZHANGQIKUOZENGDEPINGJINGWENTI,QIDANBAIHECHENGGONGNENG、NIAOSUSHENGCHENG、ANQINGCHUHECUGANZAISHENGYINZIFENMIGONGNENGJIAOCHUANTONGRENGONGGANXIBAOYOUXIANZHUTIGAO,JIANLILEQUANXINDE、KECHIXUKUOZENGDEGONGNENGXINGRENGANXIBAOZHU。

极速飞艇LINGWAI,GAITUANDUISHEJIDECHUANGXINXINGQIYEJIAOHUSHISHENGWUFANYINGQI,YIFANGMIANTIGAOLEYINGYANGHEYANGQIJIAOHUANXIAOLV,BAOZHENGLEXIBAOKUAISUKUOZENG,LINGYIFANGMIANLIYONGTESHUDEZAITIJIEGOUCUJINXIBAOZAIKUOZENGGUOCHENGZHONGXINGCHENGWENDINGDE3DJIEGOU,JINYIBUTIGAOLEGANXIBAODEHECHENGYUJIEDUGONGNENG。JIANGRENGANXIBAOYUFANYINGQIMOKUAICHUANGXINZUHESHEJICHUQIYEJIAOHUSHIXINXINGSHENGWURENGONGGANZHICHIXITONG(Air-liquid interactive bioartificial liver,Ali-BAL),KEFULEYIWANGFANYINGQIDEJIAOHUANXIAOLVDI、PEIYANGCHENGBENGAO、ZHOUQIZHANG、XIBAOWUFAXINGCHENG3DJIEGOUDENGQUEDIAN,SHIDESHENGWURENGONGGANXINGNENGDAFUTISHENG。

JIANGAli-BALXITONGYINGYONGYUYAOWUYOUDAODE18TOUGANSHUAIJIEXIAOZHUMOXINGDEZHILIAO,ZHENGMINGLEGAIXITONGDEANQUANXINGHEYOUXIAOXING:GANSHUAIJIEXIAOZHUJINGGUO3XIAOSHIDEZHILIAO,QUANBUCUNHUO,XIANZHUTIGAOLEGANSHUAIJIEDONGWUSHENGCUNLV,MINGXIANGAISHANGANXINGNAOBINGZHENGZHUANG、TIGAONINGXUEZHIBIAOHENEIHUANJINGDEWENDINGXING、JIANGDILEXUEANSHUIPINGHEYANZHENGFANYING,BINGLIJIEGUOXIANSHI,Ali-BALJUYOUCUJINGANZANGZAISHENGHEGANGONGNENGZITIHUIFUDEZUOYONG。

极速飞艇TUANDUIBIAOSHI,DUIJIJIANGKAIZHANDEGUANYU“Ali-BALXITONGDUIGANSHUAIJIEHUANZHEDELINCHUANGYANJIU”FEICHANGYOUXINXIN。RUGUOGANSHUAIJIEHUANZHEJINGGUOAli-BALDEZHILIAO,QISHENGCUNLVJIYUHOUYOUMINGXIANGAISHAN,Ali-BALXITONGJIANGWEIGUANGDAGANSHUAIJIEHUANZHETIGONGCHULEGANYIZHIYIWAIDEGENGANQUAN、GENGJINGJI、GENGYOUXIAODEZHILIAOFANGSHI。

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